New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

Katsuhiko Nishimori, Yuki Takayanagi, Masahide Yoshida, Yoshiyuki Kasahara, Larry J. Young, Masaki Kawamata

研究成果: Chapter

66 被引用数 (Scopus)

抄録

To further define the function of the oxytocin receptor (OXTR) in vivo, we generated mice deficient in the Oxtr gene (Oxtr-/-). Oxtr-/- mice had no obvious deficits in fertility or sexual behaviour, but displayed several aberrations in social behaviours, including male aggression, and mother-offspring interaction. In addition, they showed novel physiological defects including obesity, and dysfunction in body temperature control when exposed to cold. We review here our new findings with Oxtr-/- mice, and introduce newly generated Oxtr-Venus knockin mice as a potential tool for examining molecular physiology of Oxtr-neurons.

本文言語English
ホスト出版物のタイトルAdvances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease
編集者Inga Neumann, Rainer Landgraf
ページ79-90
ページ数12
DOI
出版ステータスPublished - 2008

出版物シリーズ

名前Progress in Brain Research
170
ISSN(印刷版)0079-6123

ASJC Scopus subject areas

  • Neuroscience(all)

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