New anti-malarial flavonol glycoside from Hydrangeae Dulcis Folium

Nobutoshi Murakami, Huq Mohammad Mostaqul, Satoru Tamura, Sawako Itagaki, Toshihiro Horii, Motomasa Kobayashi

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Bioassay-guided fractionation of the MeOH extract of Hydrangeae Dulcis Folium resulted in isolation of a new flavonol glycoside and two known congeners as anti-malarial principles. These flavonol glycosides showed characteristic proliferation inhibition of Plasmodium falciparum at significantly low concentration without showing any cytotoxicity. In addition, several naturally occurring flavonol glycosides were also shown to exert similar anti-malarial behavior.

本文言語English
ページ(範囲)2445-2447
ページ数3
ジャーナルBioorganic and Medicinal Chemistry Letters
11
18
DOI
出版ステータスPublished - 2001 9 17

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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