Neurovascular uncoupling under mild hypoxic hypoxia: An EEG-fMRI study in rats

Akira Sumiyoshi, Hideaki Suzuki, Hiroaki Shimokawa, Ryuta Kawashima

研究成果: Article査読

16 被引用数 (Scopus)

抄録

The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation83.6±12.1%) induced significant reductions in fMRI responses (P0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.

本文言語English
ページ(範囲)1853-1858
ページ数6
ジャーナルJournal of Cerebral Blood Flow and Metabolism
32
10
DOI
出版ステータスPublished - 2012 10

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学
  • 循環器および心血管医学

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