Neuromodulator octopamine attenuates extrajunctional glutamate sensitivity in insect muscle

Daisuke Yamamoto, Sachiyo Ishikawa

    研究成果: Article査読

    4 被引用数 (Scopus)

    抄録

    Octopamine was found to decrease extrajunctional, but not junctional glutamate responses, in mealworm neuromuscular preparations. This action of octopamine was mimicked by forskolin, 8‐(4‐chlorophenylthio)‐adenosine 3′:5′‐cyclic monophosphate (CPT‐cyclic AMP), and 8‐bromoguanosine 3′:5′‐cyclic monophosphate (8‐bromo‐cyclic GMP), but not by 1,2‐oleoylacetylglycerol (OAG), a protein kinase C activator. We suggest that the octopamine‐induced reduction in the glutamate sensitivity of extrajunctional membranes may enable the muscle to more closely follow its neuronal input by preventing a depolarization (and hence a conductance increase) due to the discharge of unsequestered transmitter molecules at nonsynaptic sites.

    本文言語English
    ページ(範囲)265-272
    ページ数8
    ジャーナルArchives of Insect Biochemistry and Physiology
    18
    4
    DOI
    出版ステータスPublished - 1991

    ASJC Scopus subject areas

    • 生理学
    • 生化学
    • 昆虫科学

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