Near-field fluorescence imaging of single molecules with a resolution in the range of 10 nm

N. Hosaka, T. Saiki

研究成果: Article査読

63 被引用数 (Scopus)

抄録

We demonstrate fluorescence imaging of single molecules, by near-field scanning optical microscopy (NSOM), using the illumination-collection mode of operation, with an aperture probe. Fluorescence images of single dye molecules were obtained with a spatial resolution of 15 nm, which is smaller than the diameter of the aperture (20 nm) of the probe employed. Such super-resolution may be attributable to non-radiative energy transfer from the molecules to the coated metal of the probe since the resolution obtained in the case of conventional NSOM is limited to 30-50 nm due to penetration of light into the metal.

本文言語English
ページ(範囲)362-364
ページ数3
ジャーナルJournal of Microscopy
202
2
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学

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