NATRIURETIC EFFECT OF TMB‐8 IN ANAESTHETIZED DOGS

Akira Takahara, Aichi Ogasawara, Mizue Suzuki‐Kusaba, Hiroaki Hisa, Susumu Satoh

研究成果: Article査読

1 被引用数 (Scopus)

抄録

1. Effects of 8‐(N,N‐diethylamino)octyl‐3,4,5‐trimethoxybenzoate hydrochloride (TMB‐8), an inhibitor of intracellular calcium release, on renal function were examined in anaesthetized dogs. 2. Intrarenal arterial infusion of TMB‐8 (0.03 and 0.1 mg/kg per min) increased urine flow rate, urinary sodium excretion and fractional excretion of sodium without affecting blood pressure, renal blood flow or glomerular filtration rate. 3. The results suggest that TMB‐8 inhibits tubular sodium reabsorption to induce natriuresis.

本文言語English
ページ(範囲)255-258
ページ数4
ジャーナルClinical and Experimental Pharmacology and Physiology
18
4
DOI
出版ステータスPublished - 1991 4

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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