N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome

Tetsuyuki Kitamoto, Tamaki Muramoto, Caroline Hilbich, Konrad Beyreuther, Jun Tateishi

研究成果: Article査読

48 被引用数 (Scopus)

抄録

Kuru plaques are one of the pathological hallmarks in Gerstmann-Sträussler syndrome, and are composed of prion protein (PrP). To elucidate whether N-terminal sequence of Prp is related to amygdaloid formation in vivo, we prepared antibody against synthetic N-terminal peptide (anti-PrP-N). Anti-PrP-N immunolabeled kuru plaques positively. Positive reactions were observed in the periphery of large kuru plaque cores, but not in the center. It is therefore postulated that one of the modification of Prp is N-terminal truncation.

本文言語English
ページ(範囲)319-321
ページ数3
ジャーナルBrain research
545
1-2
DOI
出版ステータスPublished - 1991 4月 5
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

フィンガープリント

「N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Sträussler syndrome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル