N-(F-18)-Flouoroacetyl-D-Glucosamine: A New Positron Labeled Pharmaceutical for Cancer Study

Takehiko Fujiwara, Masatoshi Itoh, Kazuo Kubota, Tachio Sato, Jutarou Takahashi, Yoshinao Abe, Hiroshi Fukuda, Masao Tada, Ren Iwata, Tatsuo Ido, Kazunori Sato

研究成果: Article査読

1 被引用数 (Scopus)

抄録

In order to evaluate the role of hexosamine metabolism in tumor tissue, we studied the biodistribution of N-(F-18)- fluoroacetyl-D-glucosamine (FAGlu) in male Donryu rats bearing poorly differentiated hepatomas (AH109A and AH272). Compare with the former result of the high tumor uptake of FAGlu in C3H/He mice bearing well differentiated spontaneous hepatoma, the tumor uptakes of FAGlu in these tumors showed the lower values. This suggested that spontaneous hepatoma maintained a high activity of glucosamine metabolism, while poorly differentiated hepatoma had little activity. Metabolism of glucosamine in tumor tissue may be another marker for characterizing tumors. We also discuss the tissue distribution of new F-18 labeled hexosamines, N-(F-18)-fluoroacetyl-D-mannosamine and N-(F-18)- fluoroacetyl-D-galactosamine in tumor bearing rats.

本文言語English
ページ(範囲)317-321
ページ数5
ジャーナルTohoku Journal of Experimental Medicine
168
2
DOI
出版ステータスPublished - 1992

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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