Mutations of the p53 gene, including an intronic point mutation, in colorectal tumors

Chikashi Ishioka, Toshiaki Sato, Makio Gamoh, Takao Suzuki, Hiroyuki Shibata, Ryunosuke Kanamaru, Akira Wakui, Tadasu Yamazaki

研究成果: Article査読

17 被引用数 (Scopus)

抄録

In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.

本文言語English
ページ(範囲)901-906
ページ数6
ジャーナルBiochemical and biophysical research communications
177
3
DOI
出版ステータスPublished - 1991 6月 28

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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