Mutant selection window of disinfectants for Staphylococcus aureus and Pseudomonas aeruginosa

Masato Kawamura, Shigeru Fujimura, Koichi Tokuda, Tetsuji Aoyagi, Shiro Endo, Hajime Kanamori, Akira Watanabe, Mitsuo Kaku

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Objectives: The aim of this study was to determine the mutant selection window (MSW) of various disinfectants against Staphylococcus aureus and Pseudomonas aeruginosa clinical isolates to determine the tendency of these strains to acquire resistance to disinfectants. Methods: A total of 60 S. aureus isolates [30 methicillin-resistant S. aureus (MRSA) and 30 methicillin-susceptible S. aureus (MSSA)] and 30 P. aeruginosa, including 2 multidrug-resistant P. aeruginosa (MDRP), were collected in Japan. The minimum inhibitory concentrations (MICs) and mutant prevention concentrations (MPCs) of disinfectants, including sodium hypochlorite (NaOCl), against these strains were established to determine the MSW. Results: The MSW50, MSW80 and MSW100 for sodium hypochlorite against S. aureus and P. aeruginosa were 4×, 8× and 16× MIC, respectively. Strains surviving in the sodium hypochlorite MSW remained at a concentration of ≤0.3% (≤3072 μg/mL). Conclusions: This is the first evaluation of the bactericidal activity against S. aureus and P. aeruginosa strains surviving in the MSW of disinfectants. Environmental disinfection at low concentrations of sodium hypochlorite does not kill micro-organisms. Proper use of sodium hypochlorite shows a bactericidal effect against various pathogenic micro-organisms and is inexpensive, making it frequently used globally.

本文言語English
ページ(範囲)316-320
ページ数5
ジャーナルJournal of Global Antimicrobial Resistance
17
DOI
出版ステータスPublished - 2019 6

ASJC Scopus subject areas

  • 微生物学
  • 免疫アレルギー学
  • 免疫学
  • 微生物学(医療)

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