Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

Shinsuke Taki, Takeo Sato, Kouetsu Ogasawara, Taeko Fukuda, Mitsuharu Sato, Shigeaki Hida, Gen Suzuki, Masao Mitsuyama, Eun Hee Shin, Soumei Kojima, Tadatsugu Taniguchi, Yoshihiro Asano

研究成果: Article査読

304 被引用数 (Scopus)

抄録

Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice tacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.

本文言語English
ページ(範囲)673-679
ページ数7
ジャーナルImmunity
6
6
DOI
出版ステータスPublished - 1997 6月
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 感染症

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