Multimodal functional analysis platform: 4. Optogenetics-induced oscillatory activation to explore neural circuits

Hajime Mushiake, Tomokazu Ohshiro, Shin ichiro Osawa, Ryosuke Hosaka, Norihiro Katayama, Tetsu Tanaka, Hiromu Yawo, Makoto Osanai

研究成果: Chapter

抄録

To elucidate neural mechanisms underlying oscillatory phenomena in brain function, we have developed optogenetic tools and statistical methods. Specifically, opto-current-clamp induced oscillation reveals intrinsic frequency preferences in the neural circuits by oscillatory resonance. Furthermore, resonance or entrainment to intrinsic frequency is state-dependent. When resonance phenomena go beyond a certain range, it could even induce epileptic seizure in highly reproducible manner. We are able to study how seizures start, develop, and stop in neural circuits. Therefore, the optogenetics-induced oscillatory activation is a powerful tool in neuroscience research.

本文言語English
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版社Springer
ページ501-509
ページ数9
DOI
出版ステータスPublished - 2021

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1293
ISSN(印刷版)0065-2598
ISSN(電子版)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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