Multicenter study of FK 037 in chronic respiratory infection

Rinzo Soejima, Yoshito Niki, Niro Okimoto, Osamu Moriya, Akira Watanabe, Yushi Nakai, Yoshihiro Honda, Shigeo Takizawa, Mikae Nakamura, Kaoru Shimada, Yasuyuki Sano, Norihisa Akiyama, Yasuko Tanaka, Hiroyuki Kobayashi, Susumu Sakayori, Hiroshi Miura, Fumio Matsumoto, Takeo Imai, Koji Yoshikawa, Shigeki OdagiriYoshihiro Hirai, Yasuhiro Yoshiike, Midori Sumitomo, Nobuki Aoki, Toshihiko Takeuchi, Yasuo Yamada, Hidekazu Hanaki, Makoto Kawakami, Fumio Miki, Nobuhiro Narita, Keiichi Mikasa, Masayoshi Sawaki, Toshiharu Matsushima, Makoto Kimura, Takao Sasaki, Yukio Matsumoto, Yuji Sugimoto, Jiro Takahara, Jiro Fujita, Tadashi Kamei, Hozumi Yamada, Osamu Kato, Yosuke Aoki, Kaimei Nakahara, Kohei Hara, Shigeru Kohno, Hironobu Kaga, Keizo Matsumoto, Hiroshi Watanabe, Akemi Ohmori, Moritoshi Akiyama, Yoshiaki Utsunomiya, Kazunori Oishi, Tsuyoshi Nagatake, Masaru Nasu, Yoichiro Goto, Tohru Yamazaki

    研究成果: Article査読

    9 被引用数 (Scopus)

    抄録

    A multicenter open study was conducted to evaluate the clinical efficacy, safety and optimal effective dosage of FK 037 in chronic respiratory tract infections. 1. The total number of patients enrolled was 55, 3 of whom were judged to be “unkown” in the assessment of clinical efficacy. 2. The clinical efficacy in 52 patients was judged to be “excellent” in 14 and “good” in 34 an efficacy rate of 92.3%. The efficacy rates according to dosage were 90.0% at 0.5 g×2/day, 93.1% at 1.0 g×2/day and 92.3% at 2.0g×2/day. 3. The bacteriological effects in 31 patients were “eradicated” in 26, “decreased” in 3 and “unchanged” in 2, for an eradication rate of 83.9%. 4. As side effects, a small papule was observed in 1 patient, and abnormal laboratory findings were observed in 7 patients. From the above results, we concluded that 1.0 g×2/day of FK 037 was useful in chronic respiratory tract infections.

    本文言語English
    ページ(範囲)1162-1175
    ページ数14
    ジャーナルChemotherapy
    42
    10
    DOI
    出版ステータスPublished - 1994

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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