Multi-capillary based optical sensors for highly sensitive protein detection

Yasuhira Okuyama, Takashi Katagiri, Yuji Matsuura

研究成果: Conference contribution

抄録

A fluorescence measuring method based on glass multi-capillary for detecting trace amounts of proteins is proposed. It promises enhancement of sensitivity due to effects of the adsorption area expansion and the longitudinal excitation. The sensitivity behavior of this method was investigated by using biotin-streptavidin binding. According to experimental examinations, it was found that the sensitivity was improved by a factor of 70 from common glass wells. We also confirmed our measuring system could detect 1 pg/mL of streptavidin. These results suggest that multi-capillary has a potential as a high-sensitive biosensor.

本文言語English
ホスト出版物のタイトルBiomedical Imaging and Sensing Conference
編集者Yasuhiro Awatsuji, Osamu Matoba, Yoshihisa Aizu, Toyohiko Yatagai
出版社SPIE
ISBN(電子版)9781510610033
DOI
出版ステータスPublished - 2017 1 1
イベント3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan
継続期間: 2017 4 192017 4 21

出版物シリーズ

名前Proceedings of SPIE - The International Society for Optical Engineering
10251
ISSN(印刷版)0277-786X
ISSN(電子版)1996-756X

Other

Other3rd Biomedical Imaging and Sensing Conference
CountryJapan
CityYokohama
Period17/4/1917/4/21

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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