MRP5b/SMRP mRNA is highly expressed in metallothionein- deficient mouse liver

Toshihiro Suzuki; Mika Agui; Tadayasu Togawa; Akira Naganuma; Kazuto Nishio; Shinzo Tanabe

doi:10.1248/jhs.49.524

MRP5b/SMRP mRNA is highly expressed in metallothionein- deficient mouse liver

Toshihiro Suzuki, Mika Agui, Tadayasu Togawa, Akira Naganuma, Kazuto Nishio, Shinzo Tanabe

薬学研究科・生命薬科学専攻

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

To investigate whether multidrug resistance protein 5 (MRP5) functions as a xenobiotic detoxification factor, we measured MRP mRNA expression levels in metallothionein (MT)-I, II knockout mouse, and the results showed that MRP5b/SMRP, a splicing variant of MRP5, was highly expressed in the liver of MT-I, -II null mice.

本文言語	English
ページ（範囲）	524-526
ページ数	3
ジャーナル	Journal of Health Science
巻	49
号	6
DOI	https://doi.org/10.1248/jhs.49.524
出版ステータス	Published - 2003 12

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

文献へのアクセス

10.1248/jhs.49.524

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引用スタイル

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abstract = "To investigate whether multidrug resistance protein 5 (MRP5) functions as a xenobiotic detoxification factor, we measured MRP mRNA expression levels in metallothionein (MT)-I, II knockout mouse, and the results showed that MRP5b/SMRP, a splicing variant of MRP5, was highly expressed in the liver of MT-I, -II null mice.",

keywords = "Metallothionein, Multidrug resistance protein, Multidrug resistance protein 5",

author = "Toshihiro Suzuki and Mika Agui and Tadayasu Togawa and Akira Naganuma and Kazuto Nishio and Shinzo Tanabe",

year = "2003",

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AU - Suzuki, Toshihiro

AU - Agui, Mika

AU - Togawa, Tadayasu

AU - Naganuma, Akira

AU - Nishio, Kazuto

AU - Tanabe, Shinzo

PY - 2003/12

Y1 - 2003/12

N2 - To investigate whether multidrug resistance protein 5 (MRP5) functions as a xenobiotic detoxification factor, we measured MRP mRNA expression levels in metallothionein (MT)-I, II knockout mouse, and the results showed that MRP5b/SMRP, a splicing variant of MRP5, was highly expressed in the liver of MT-I, -II null mice.

AB - To investigate whether multidrug resistance protein 5 (MRP5) functions as a xenobiotic detoxification factor, we measured MRP mRNA expression levels in metallothionein (MT)-I, II knockout mouse, and the results showed that MRP5b/SMRP, a splicing variant of MRP5, was highly expressed in the liver of MT-I, -II null mice.

KW - Metallothionein

KW - Multidrug resistance protein

KW - Multidrug resistance protein 5

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