Mortality rates amongst mice with endogenous septicaemia caused by Pseudomonas aeruginosa isolates from various clinical sources

N. Furuya, Y. Hirakata, K. Tomono, T. Matsumoto, K. Tateda, M. Kaku, K. Yamaguchi

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Mice that had been treated with cyclophosphamide and ampicillin were fed with Pseudomonas aeruginosa. These procedures induced an endogenous septicaemia under conditions mimicking the pathophysiology of the disease in man. This model was used to compare the mortality rates in mice infected with P. aeruginosa isolates from various clinical sources. Mortality rates in mice given isolates from blood cultures had a broad range (0-100%), but the mean rate was significantly higher than with isolates from other infection sites. Moreover, blood isolates persisted in the intestines of mice after oral inoculation, whereas most isolates from other sources were gradually eliminated. Most P. aeruginosa isolates from blood cultures produced significantly higher levels of exotoxin A and total proteases than isolates from other infection sites. Amongst the blood isolates, all but one of the lethal strains produced large quantities of exotoxin A or total proteases or both. Taken together, the results suggest that the ability of P. aeruginosa to adhere to the intestinal tract and to produce high levels of exo-enzymes may contribute to the development of fatal septicaemia.

本文言語English
ページ(範囲)141-146
ページ数6
ジャーナルJournal of Medical Microbiology
39
2
DOI
出版ステータスPublished - 1993

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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