Mortality effects of prolonged hemoperfusion therapy using a polymyxin b-immobilized fiber column for patients with septic shock: A sub-analysis of the DESIRE trial

Yu Kawazoe, Tetsuya Sato, Noriko Miyagawa, Yuta Yokokawa, Shigeki Kushimoto, Kyohei Miyamoto, Yoshinori Ohta, Takeshi Morimoto, Hitoshi Yamamura

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Background/Aims: The optimal duration of hemoperfusion therapy with a polymyxin B-immobilized fiber column has not yet been verified. Methods: This analysis examined whether hemoperfusion therapy with a polymyxin B-immobilized fiber column lasting longer than 2 h (prolonged polymyxin) improved outcomes for patients with septic shock compared to 2-h polymyxin therapy (sub-analysis of data from the DESIRE trial). Results: The 2-h and prolonged polymyxin groups contained 22 and 14 patients, respectively. Both groups had similar characteristics. The polymyxin duration per session in the prolonged polymyxin group was significantly longer (median, 5.5 h) than in the 2-h polymyxin group (p < 0.01). The 28-day mortality rate was significantly higher in the 2-h polymyxin group (7, 31.8%) than in the prolonged polymyxin group (0, 0%; p = 0.019). Conclusion: Prolonged polymyxin therapy might be associated with better clinical outcomes than 2-h polymyxin therapy in patients with septic shock. Video Journal Club "Cappuccino with Claudio Ronco" at http://www.karger.com/?doi=491744.

本文言語English
ページ(範囲)309-314
ページ数6
ジャーナルBlood Purification
46
4
DOI
出版ステータスPublished - 2018 10 1

ASJC Scopus subject areas

  • 血液学
  • 腎臓病学

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