Molecular pharmacology of voltage-dependent calcium channels

Yasuo Mori, Gabor Mikala, Gyula Varadi, Tsutomu Kobayashi, Sheryl Koch, Minoru Wakamori, Arnold Schwartz

研究成果: Review article査読

94 被引用数 (Scopus)

抄録

Voltage-dependent Ca2+ channels serve as the only link to transduce membrane depolarization into cellular Ca2+-dependent reactions. A wide variety of chemical substances that have the ability to modulate Ca2+ channels have been demonstrated both for their clinic utility and for importance in elucidating the molecular basis of various biological responses. Recently, introduction of molecular biology to pharmacology has brought a great deal of information about the molecular basis of drug action in Ca2+ channels. In this review, we attempt to overview recent progress in understanding the interactions between Ca2+ channels and their blockers, namely Ca2+ antagonists, from a molecular and structural point of view.

本文言語English
ページ(範囲)83-109
ページ数27
ジャーナルJapanese Journal of Pharmacology
72
2
DOI
出版ステータスPublished - 1996
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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