Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease

Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka

研究成果: Review article査読

662 被引用数 (Scopus)

抄録

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as synaptic vesicle precursors, neurotransmitter and neurotrophic factor receptors, and mRNAs within axons, dendrites, and synapses. Recent studies have begun to clarify the mechanisms of cargo selection and directional transport in subcellular compartments. Furthermore, molecular genetics has revealed unexpected roles for molecular motors in brain wiring, neuronal survival, neuronal plasticity, higher brain function, and control of central nervous system and peripheral nervous system development. Finally, it is also evident that molecular motors are critically involved in neuronal disease pathogenesis. Thus, molecular motor research is becoming an exciting frontier of neuroscience.

本文言語English
ページ(範囲)610-638
ページ数29
ジャーナルNeuron
68
4
DOI
出版ステータスPublished - 2010 11 18
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

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