Molecular evolutionary analysis of yeast protein interaction network

Soichi Ogishima, Takeshi Hase, So Nakagawa, Yasuhiro Suzuki, Hiroshi Tanaka

研究成果: Conference contribution

抄録

To understand life as biological system, evolutionary understanding is indispensable. Protein interactions data are rapidly accumulating and are suitable for system-level evolutionary analysis. We have analyzed yeast protein interaction network by both mathematical and biological approaches. In this poster presentation, we inferred the evolutionary birth periods of yeast proteins by reconstructing phylogenetic profile. It has been thought that hub proteins that have high connection degree are evolutionary old. But our analysis showed that hub proteins are entirely evolutionary new. We also examined evolutionary processes of protein complexes. It showed that member proteins of complexes were tend to have appeared in the same evolutionary period. Our results suggested that protein interaction network evolved by modules that form the functional unit. We also reconstructed standardized phylogenetic trees and calculated evolutionary rates of yeast proteins. It showed that there is no obvious correlation between evolutionary rates and connection degrees of yeast proteins. COPYRIGHT

本文言語English
ホスト出版物のタイトルProceedings - Wec 05
ホスト出版物のサブタイトルFourth World Enformatika Conference
編集者C. Ardil
ページ245-248
ページ数4
出版ステータスPublished - 2005
イベントWec 05: Fourth World Enformatika Conference - Istanbul, Turkey
継続期間: 2005 6 242005 6 26

出版物シリーズ

名前Proceedings - Wec 05: Fourth World Enformatika Conference
6

Other

OtherWec 05: Fourth World Enformatika Conference
国/地域Turkey
CityIstanbul
Period05/6/2405/6/26

ASJC Scopus subject areas

  • 工学(全般)

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