Molecular diagnosis of tumor angiogenesis and anti-angiogenic cancer therapy

研究成果: Review article査読

49 被引用数 (Scopus)

抄録

Angiogenesis is regulated by the balance of proangiogenic factors and angiogenesis inhibitors, and the imbalance of these regulators is the cause of pathological angiogenesis, including tumor angiogenesis. Angiogenesis is required for tumor growth and metastasis, and thus constitutes an important target for the control of tumor progression. While the benefit of anti-angiogenic therapy is potentially profound, limitations have also been recognized by the results obtained thus far by clinical trials. Precise understanding of the process of angiogenesis should lead us to new regimens for more efficient anti-angiogenic therapy. This review focuses on our current understanding of the molecular mechanism of tumor angiogenic and the status of the anti-angiogenesis approach for cancer treatment.

本文言語English
ページ(範囲)200-206
ページ数7
ジャーナルInternational Journal of Clinical Oncology
8
4
DOI
出版ステータスPublished - 2003 8 1

ASJC Scopus subject areas

  • 外科
  • 血液学
  • 腫瘍学

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