Molecular cloning of rat cDNA for cytosolic phospholipase A2 and the increased gene expression in the dentate gyrus following transient forebrain ischemia

Yuji Owada, Teiji Tominaga, Takashi Yoshimoto, Hisatake Kondo

研究成果: Article査読

68 被引用数 (Scopus)

抄録

Rat cytosolic phospholipase A2 (cPLA2) cDNA was cloned from rat brain. The cDNA showed a high homology of 90% in the nucleotide sequence of the coding region with the human counterpart. By in situ hybridization, the gene expression for cPLA2 was detected in the hippocampus, olfactory bulb, and cerebellar granular cells at very low level of normal rats. The expression was markedly increased in the dentate granule cells of postischemic rat brain. This alteration of the gene expression was discussed in relation to the free fatty acid-mediated neurotoxicity.

本文言語English
ページ(範囲)364-368
ページ数5
ジャーナルMolecular Brain Research
25
3-4
DOI
出版ステータスPublished - 1994 9

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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