We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Cη. Sequence analysis suggests that PP2Cη, PP2Cζ and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Cη had extremely low activity against α-casein compared with PP2Cα and was localized mainly in cell nuclei, suggesting that PP2Cη dephosphorylates a unique nuclear protein(s) in the cells.
|ジャーナル||Biochimica et Biophysica Acta - Gene Structure and Expression|
|出版ステータス||Published - 2003 11 30|
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