Molecular basis of canalization in an ascidian species complex adapted to different thermal conditions

Atsuko Sato, Takeshi Kawashima, Manabu Fujie, Samantha Hughes, Noriyuki Satoh, Sebastian M. Shimeld

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary change. Study of laboratory model species has uncovered several possible canalization mechanisms, however, we still do not understand how the level of buffering is controlled in natural populations. We exploit wild populations of the marine chordate Ciona intestinalis to show that levels of buffering are maternally inherited. Comparative transcriptomics show expression levels of genes encoding canonical chaperones such as Hsp70 and Hsp90 do not correlate with buffering. However the expression of genes encoding endoplasmic reticulum (ER) chaperones does correlate. We also show that ER chaperone genes are widely conserved amongst animals. Contrary to previous beliefs that expression level of Heat Shock Proteins (HSPs) can be used as a measurement of buffering levels, we propose that ER associated chaperones comprise a cellular basis for canalization. ER chaperones have been neglected by the fields of development, evolution and ecology, but their study will enhance understanding of both our evolutionary past and the impact of global environmental change.

本文言語English
論文番号16717
ジャーナルScientific reports
5
DOI
出版ステータスPublished - 2015 11月 18
外部発表はい

ASJC Scopus subject areas

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