Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells

Yosuke Shimodaira, Seiichi Takahashi, Yoshitaka Kinouchi, Katsuya Endo, Hisashi Shiga, Yoichi Kakuta, Masatake Kuroha, Tooru Shimosegawa

研究成果: Article査読

38 被引用数 (Scopus)

抄録

To explore the relationship between UPR and autophagy in intestinal epithelial cells, we investigated whether autophagy was induced by endoplasmic reticulum (ER) stress in colon cancer cell lines. We demonstrated that autophagy was induced by ER stress in HT29, SW480, and Caco-2 cells. In these cells, inositol-requiring enzyme1α (IRE1α) and C/EBP homologous protein (CHOP) were involved in the ER stress-autophagy pathway, and CHOP was a regulator of IRE1α protein expression. Our findings suggest that CHOP promotes IRE1α and autophagy especially in ER stress conditions. This study will provide important insights into the disclosure of the ER stress-autophagy pathway.

本文言語English
ページ(範囲)524-533
ページ数10
ジャーナルBiochemical and biophysical research communications
445
2
DOI
出版ステータスPublished - 2014 3 7

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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「Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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