Modular Synthesis of Multisubstituted Furans through Palladium-Catalyzed Three-Component Condensation of Alkynylbenziodoxoles, Carboxylic Acids, and Imines

Junliang Wu, Naohiko Yoshikai

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Mild and regiocontrolled synthesis of a multisubstituted furan is achieved through Pd(OAc)2-catalyzed room-temperature condensation of an alkynylbenziodoxole, a carboxylic acid, and an enolizable ketimine, which contribute to C1, CO, and C2 fragments, respectively, to the furan skeleton. The reaction tolerates a broad range of functional groups in each of the reaction components, and enables highly modular and flexible synthesis of variously substituted furans. The reaction is particularly effective for the rapid generation of tri- and tetraarylfurans and furan-containing oligoarylenes without relying on conventional cross-coupling chemistry.

本文言語English
ページ(範囲)11107-11111
ページ数5
ジャーナルAngewandte Chemie - International Edition
54
38
DOI
出版ステータスPublished - 2015 9月 14
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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