Modification of a glassy carbon electrode with diols for the suppression of electrode fouling in biological fluids

Bei Guo, Jun Ichi Anzai, Tetsuo Osa

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The surface of a glassy carbon (GC) electrode was modified covalently with ethyleneglycol, diethyleneglycol, 1,2-propanediol, and 1,3-propanediol by electrochemical oxidation in order to suppress the electrode fouling originating from non-specific adsorption of serum proteins. Human serum albumin (HSA) was adsorbed significantly on the surface of a bare GC electrode, which was monitored by cyclic voltammetry in the presence of Fe(CN)4-6/Fe(CN)3-6 ions. In contrast, the diol-modified GC electrodes were scarcely fouled in HSA solution and even in human serum. The results were explained reasonably based on the hydrophilic nature of the diol-modified GC surface.

本文言語English
ページ(範囲)860-862
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
44
4
DOI
出版ステータスPublished - 1996 4

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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