Modeling strategy for background compensation in repeat cerebral blood flow quantitation with diffusible tracers

H. Iida, H. Watabe, M. Shidahara, K. Min Kim, S. Takikawa, T. Ogura, K. Hayashida, Y. Ishida

研究成果: Paper査読

1 被引用数 (Scopus)

抄録

A method has been developed for repeat quantitation of regional cerebral blood flow (rCBF) using a diffusible tracer such as O-15 water (H2 15O) and I-123 iodo-amphetamine (123IMP). The background activity distribution due to the previous tracer administration was formulated according to a compartment model, so as to allow initiation of the next scan while residual radioactivity exists, minimizing the intervals between scans. This background distribution was estimated from the previous scan with the minimum enhancement of the statistical noise. Theoretical simulation study was carried out, and demonstrated that the estimated images of the transient tracer distribution are highly weighted on transient rCBF immediately after the tracer administration, and that the change of rCBF after a certain period has only small contribution to the estimated tracer distributions. Another set of simulation study showed that estimated rCBF was sensitive to the transient rCBF only immediately after the tracer administration, and that the change after a certain period does not contribute to the rCBF estimated by the present approach. This technique was then applied to a clinical test-retest study using IMP and SPECT. Reproducibility of rCBF quantified by this approach was less than 5% in 5 studies performed at Rest-Rest condition, and vascular reactivity determined by a rest-vasolidating drug stimulation (Rest-Diamox) on 5 healthy volunteers appeared to be 40%, which was in an agreement with literature value. We thus conclude that repeat rCBF quantitation is feasible with considerably shorter intervals than the present protocol, and can be applied to clinical studies.

本文言語English
ページ18/34-18/39
出版ステータスPublished - 2000
外部発表はい
イベント2000 IEEE Nuclear Science Symposium Conference Record - Lyon, France
継続期間: 2000 10 152000 10 20

Other

Other2000 IEEE Nuclear Science Symposium Conference Record
国/地域France
CityLyon
Period00/10/1500/10/20

ASJC Scopus subject areas

  • 放射線
  • 核物理学および高エネルギー物理学
  • 放射線学、核医学およびイメージング

フィンガープリント

「Modeling strategy for background compensation in repeat cerebral blood flow quantitation with diffusible tracers」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル