Modeling of segmentation clock mechanism in presomitic mesoderm

A. Kazama, Akihiro Karashima, Norihiro Katayama, M. Nakao

研究成果: Conference contribution

3 被引用数 (Scopus)

抄録

Somite is sequentially generated in a head-to-tail order by segmentation of the mesenchymal tissue called presomitic mesoderm (PSM). The segmentation occurs periodically at the anterior end of the PSM, and this periodic segmentation has been suggested to be regulated by a molecular clock. In mouse PSM, the segmentation-related genes change their expression every 120 minutes, and this cyclic expression is essential for regular somite segmentation. In this study, a molecular mechanism of segmentation clock involving Wnt and Delta-Notch signaling pathways is modeled, and reality of the model structure is investigated through simulating biological findings. One dimensional array of the cellular clock models is constructed to simulate spatio-temporal dynamics of the gene-expressions in the PSM. The simulation result suggests that the Wnt gradient across the PSM is involved in the dynamics under concern.

本文言語English
ホスト出版物のタイトルProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ホスト出版物のサブタイトルEngineering the Future of Biomedicine, EMBC 2009
出版社IEEE Computer Society
ページ3267-3270
ページ数4
ISBN(印刷版)9781424432967
DOI
出版ステータスPublished - 2009
イベント31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
継続期間: 2009 9月 22009 9月 6

出版物シリーズ

名前Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
国/地域United States
CityMinneapolis, MN
Period09/9/209/9/6

ASJC Scopus subject areas

  • 細胞生物学
  • 発生生物学
  • 生体医工学
  • 医学(全般)

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