A method has been developed for repeat quantitation of physiological parameters from multiple administrations of radiotracers. The background activity distribution due to the previous tracer administration was formulated according to a compartment model, so as to allow initiation of the next scan while residual radioactivity exists, minimizing the intervals between scans, with the minimum enhancement of the statistical noise. Theoretical simulation for repeat administration of H215O demonstrated that the transient tracer distribution was highly weighted on transient rCBF immediately after the previous tracer administration, and that the change of rCBF after a certain period has only small contribution to the estimated tracer distributions. Another set of simulation showed that estimated rCBF was sensitive to the transient rCBF only immediately after the tracer administration, and that the change after a certain period does not contribute to the rCBF estimated by the present approach. This technique was then applied to a clinical study of serial administration of H215O and 15O2 and demonstrated that the yielded CBF and CMRO2 are well agreed with those determined based on the classical 3-step measurements. We thus conclude that quantitation of physiological parameters can be determined by PET with much shorter examination interval as compared with the previous study protocol.
|ジャーナル||IFAC Proceedings Volumes (IFAC-PapersOnline)|
|出版ステータス||Published - 2003 1 1|
|イベント||5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australia|
継続期間: 2003 8 21 → 2003 8 23
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