Mixed Corticomedullary Tumor Accompanied by Unilateral Aldosterone-Producing Adrenocortical Micronodules: A Case Report

Sawa Yoshida, Naru Babaya, Hiroyuki Ito, Yoshihisa Hiromine, Yasunori Taketomo, Fumimaru Niwano, Shuzo Imamura, Yuto Yamazaki, Hironobu Sasano, Yumiko Kawabata, Shinsuke Noso, Hiroshi Ikegami

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Mixed corticomedullary tumors (MCMTs) are rare and comprise medullary and cortical cells in a single adrenal tumor. The mechanisms underlying their development have not been fully elucidated. Here, we report a case of MCMT in a 42-year-old woman. Based on the preoperative clinical findings, the patient was diagnosed as having a pheochromocytoma with subclinical Cushing syndrome. Postoperative pathological diagnosis revealed that the tumor demonstrated morphologically distinct medullary and cortical components, which produced catecholamines and cortisol, respectively. Hybrid tumor cells producing both catecholamines and cortisol were not detected. Adrenocorticotropin (ACTH)-positive tumor cells were identified to be present in the pheochromocytoma. This ectopic production of ACTH can contribute to an autonomous cortisol production in a paracrine manner. In addition, micronodules producing aldosterone were detected in the adrenal tissue adjacent to the tumor. The simultaneous development of these 2 lesions may not be correlated with each other; however, this case confirms the importance of a detailed histopathological examination of the adrenal lesions harboring complicated hormonal abnormalities by providing pivotal and indispensable information on their pathogenesis and the possible interaction of the hormones produced in the adrenal gland.

本文言語English
論文番号bvab140
ジャーナルJournal of the Endocrine Society
5
10
DOI
出版ステータスPublished - 2021 10月 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学

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