Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation

Bo Van, Miyuki Nishi, Shinji Komazaki, Atsuhiko Ichimura, Sho Kakizawa, Keita Nakanaga, Junken Aoki, Ki Ho Park, Jianjie Ma, Tomomi Ueyama, Takehiro Ogata, Naoki Maruyama, Hiroshi Takeshima

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Mitsugumin 56 (MG56), also known as the membrane-bound O-acyl-transferase family member hedgehog acyltransferase-like, was identified as a new sarcoplasmic reticulum component in striated muscle. Mg56-knockout mice grew normally for a week after birth, but shortly thereafter exhibited a suckling defect and died under starvation conditions. In the knockout skeletal muscle, regular contractile features were largely preserved, but sarcoplasmic reticulum elements swelled and further developed enormous vacuoles. In parallel, the unfolded protein response was severely activated in the knockout muscle, and presumably disrupted muscle development leading to the suckling failure. Therefore, MG56 seems essential for postnatal skeletal muscle maturation.

本文言語English
ページ(範囲)1095-1104
ページ数10
ジャーナルFEBS Letters
589
10
DOI
出版ステータスPublished - 2015 4月 28

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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