Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia

Kuniyasu Niizuma, Hideyuki Yoshioka, Hai Chen, Gab Seok Kim, Joo Eun Jung, Masataka Katsu, Nobuya Okami, Pak H. Chan

研究成果: Review article査読

235 被引用数 (Scopus)


Mitochondria play important roles as the powerhouse of the cell. After cerebral ischemia, mitochondria overproduce reactive oxygen species (ROS), which have been thoroughly studied with the use of superoxide dismutase transgenic or knockout animals. ROS directly damage lipids, proteins, and nucleic acids in the cell. Moreover, ROS activate various molecular signaling pathways. Apoptosis-related signals return to mitochondria, then mitochondria induce cell death through the release of pro-apoptotic proteins such as cytochrome c or apoptosis-inducing factor. Although the mechanisms of cell death after cerebral ischemia remain unclear, mitochondria obviously play a role by activating signaling pathways through ROS production and by regulating mitochondria-dependent apoptosis pathways.

ジャーナルBiochimica et Biophysica Acta - Molecular Basis of Disease
出版ステータスPublished - 2010 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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