MiRNAs and regulation of cell signaling

Atsuhiko Ichimura, Yoshinao Ruike, Kazuya Terasawa, Gozoh Tsujimoto

研究成果: Review article査読

60 被引用数 (Scopus)

抄録

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding to target mRNAs in a sequence-specific manner. A large number of genes appear to be the target of miRNAs, and an essential role for miRNAs in the regulation of various conserved cell signaling cascades, such as mitogen-activated protein kinase, Notch and Hedgehog, is emerging. Extensive studies have also revealed the spatial and temporal regulation of miRNA expression by various cell signaling cascades. The insights gained in such studies support the idea that miRNAs are involved in the highly complex network of cell signaling pathways. In this minireview, we present an overview of these complex networks by providing examples of recent findings. An essential role for miRNAs in the regulation of various conserved cell signaling cascades is emerging. Extensive studies have revealed the spatio-temporal regulation of miRNA expression by these conserved cascades. The insights gained in these studies support the idea that miRNAs are involved in the highly complex network of cell signaling. In this review, we summarize these complex networks

本文言語English
ページ(範囲)1610-1618
ページ数9
ジャーナルFEBS Journal
278
10
DOI
出版ステータスPublished - 2011 5

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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