Migration of Deformable Vesicles Induced by Ionic Stimuli

Atsuji Kodama, Mattia Morandi, Ryuta Ebihara, Takehiro Jimbo, Masayuki Toyoda, Yuka Sakuma, Masayuki Imai, Nicolas Puff, Miglena I. Angelova

研究成果: Article

2 引用 (Scopus)

抜粋

We have investigated the dynamics of phospholipid vesicles composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine triggered by ionic stimuli using electrolytes such as CaCl2, NaCl, and NaOH. The ionic stimuli induce two characteristic vesicle dynamics, deformation due to the ion binding to the lipids in the outer leaflet of the vesicle and migration due to the concentration gradient of ions, that is, diffusiophoresis or the interfacial energy gradient mechanism. We examined the deformation pathway for each electrolyte as a function of time and analyzed it based on the surface dissociation model and the area difference elasticity model, which reveals the change of the cross-sectional area of the phospholipid by the ion binding. The metal ions such as Ca2+ and Na+ encourage inward budding deformation by decreasing the cross-sectional area of a lipid, whereas the hydroxide ion (OH-) encourages outward budding deformation by increasing the cross-sectional area of a lipid. When we microinjected these electrolytes toward the vesicles, a strong coupling between the deformation and the migration of the vesicle was observed for CaCl2 and NaOH, whereas for NaCl, the coupling was very weak. This difference probably originates from the binding constants of the ions.

元の言語English
ページ(範囲)11484-11494
ページ数11
ジャーナルLangmuir
34
発行部数38
DOI
出版物ステータスPublished - 2018 9 25

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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  • これを引用

    Kodama, A., Morandi, M., Ebihara, R., Jimbo, T., Toyoda, M., Sakuma, Y., Imai, M., Puff, N., & Angelova, M. I. (2018). Migration of Deformable Vesicles Induced by Ionic Stimuli. Langmuir, 34(38), 11484-11494. https://doi.org/10.1021/acs.langmuir.8b02105