MIDA1, a protein associated with Id, regulates cell growth

W. Shoji, T. Inoue, T. Yamamoto, M. Obinata

研究成果: Article査読

74 被引用数 (Scopus)

抄録

We have isolated cDNA clone encoding a protein that can associate with Id, a helix-loop-helix (HLH) protein. This protein is named MIDA1 (mouse Id associate 1), and its predicted amino acid sequence consists of Zuotin (a putative Z-DNA binding protein in yeast) homology region and tryptophan- mediated repeats similar to c-Myb oncoprotein. MIDA1 associates with the HLH region of Id with the conserved region adjacent to eukaryotic DnaJ conserved motif within the Zuotin homology region, although it does not have any canonical HLH motif. The addition of antisense oligonucleotide of MIDA1 inhibited growth of murine erythroleukemia cells without interfering with erythroid differentiation, indicating that it regulates cell growth.

本文言語English
ページ(範囲)24818-24825
ページ数8
ジャーナルJournal of Biological Chemistry
270
42
DOI
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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