Micromesh culture technique enabling cell maturation for the use of organ on a chip

Osamu Kurosawa, Takeshi Hori, Nobutaka Tani, Hiroo Iwata

研究成果: Conference contribution

抄録

Recently, we have developed a novel cell culture method named “micromesh cell culture technique”. By using this technique, hiPSCs could be differentiated into trophectoderm in base culture medium for iPS cells without any additional supplements. In this study, we used this technique at the aim of realizing maturation of organ cells to be used for "organ on a chip". In the result of HepG2, an increase in gene expression of albumin and CYP1A2 which is one of drug metabolizing enzyme was confirmed by mesh culture. In addition, By co-culturing with fibroblast on micromesh, Caco-2 showed the increase in expression of tight junction-related gene and CYP1A2.

本文言語English
ホスト出版物のタイトル22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
出版社Chemical and Biological Microsystems Society
ページ1638-1640
ページ数3
ISBN(電子版)9781510897571
出版ステータスPublished - 2018
外部発表はい
イベント22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
継続期間: 2018 11 112018 11 15

出版物シリーズ

名前22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
3

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
国/地域Taiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

ASJC Scopus subject areas

  • 化学 (全般)
  • バイオエンジニアリング
  • 化学工学(その他)
  • 制御およびシステム工学

フィンガープリント

「Micromesh culture technique enabling cell maturation for the use of organ on a chip」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル