Microfluidic generation of polydopamine gradients on hydrophobic surfaces

Xuetao Shi, Serge Ostrovidov, Yiwei Shu, Xiaobin Liang, Ken Nakajima, Hongkai Wu, Ali Khademhosseini

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Engineered surface-bound molecular gradients are of great importance for a range of biological applications. In this paper, we fabricated a polydopamine gradient on a hydrophobic surface. A microfluidic device was used to generate a covalently conjugated gradient of polydopamine (PDA), which changed the wettabilty and the surface energy of the substrate. The gradient was subsequently used to enable the spatial deposition of adhesive proteins on the surface. When seeded with human adipose mesenchymal stem cells, the PDA-graded surface induced a gradient of cell adhesion and spreading. The PDA gradient developed in this study is a promising tool for controlling cellular behavior and may be useful in various biological applications.

本文言語English
ページ(範囲)832-838
ページ数7
ジャーナルLangmuir
30
3
DOI
出版ステータスPublished - 2014 1月 28
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)
  • 凝縮系物理学
  • 表面および界面
  • 分光学
  • 電気化学

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