Microelectrochemical Approach to Induce Local Cell Adhesion and Growth on Substrates

Hirokazu Kaji, Masamitsu Kanada, Daisuke Oyamatsu, Tomokazu Matsue, Matsuhiko Nishizawa

研究成果: Article査読

87 被引用数 (Scopus)

抄録

The nature of an albumin-coated substrate that blocks protein adsorption and cell adhesion was rapidly switched to cell-adhesive by exposure to an oxidizing agent such as HBrO. This finding has enabled cellular pattern drawing even on a single-cell level by closely scanning a microelectrode above the substrate and electrochemically producing the agent at the tip of the electrode. The present microelectrochemical cell patterning is applicable even for a previously cell-patterned substrate and for a grooved substrate. These unique technical features will have impacts on a variety of cell-based studies that require the analysis of heterotypic cell-cell interactions and cellular arrangement on an uneven surface such as semiconductor devices.

本文言語English
ページ(範囲)16-19
ページ数4
ジャーナルLangmuir
20
1
DOI
出版ステータスPublished - 2004 1 6

ASJC Scopus subject areas

  • 材料科学(全般)
  • 凝縮系物理学
  • 表面および界面
  • 分光学
  • 電気化学

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