Microdistribution of alpha particles in pathological sections of tissues from thorotrast patients detected by imaging plate autoradiography

Akira Goto, Yuji Takebayashi, Duo Liu, Li Li, Tatsuyoshi Saiga, Takesaburo Mori, Akira Yamadera, Manabu Fukumoto

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Thorotrast is a colloidal suspension of radioactive 232ThO2 that naturally emits α particles (90%), β particles and γ rays (10%). Thorotrast was used as a radiographic contrast agent in the 1930s-1950s; it caused liver cancer several decades after injection because of its life-long deposition and exposure. Determination of the amount and the distribution of radioactive thorium are essential for assessment of radiation risks. We visualized α particles on ordinary archival tissue sections using an imaging plate and a BAS5000 image analyzer. Furthermore, we confirmed that the imaging system is sensitive enough to detect α particles and accurate in measuring the total amount of thorium deposited in the organ from a single tissue section. This method revealed that the amount of thorium deposited in tumor tissue is correlated to that in non-tumor tissue. Thorotrast deposition was not associated with DNA damage determined by histochemistry. In combination with histological findings, it is suggested that radioactive thorium always migrates within the deposited organs by macrophages, and that the organs are evenly exposed to α particles.

本文言語English
ページ(範囲)54-60
ページ数7
ジャーナルRadiation Research
158
1
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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