Micrococcus luteus cells and cell walls induce anaphylactoid reactions accompanied by early death and serum cytokines in mice primed with muramyl dipeptide

Toshihiko Monodane, Yoshihiro Kawabata, Haruhiko Takada

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Micrococcus luteus strains at a dose of 500 μg of whole cells caused anaphylactoid reactions leading to death in some instances within 1 h in C3H/HeN mice primed with muramyl dipeptide (MDP, 100 μg). Tumor necrosis factor (TNF) and interleukin-6 (IL-6) were induced in the serum of half and of all the surviving mice, respectively. Cell wall specimens of M. luteus so far examined also caused anaphylactoid reactions accompanied by early death and one strain induced high levels of TNF and IL-6. Cytoplasmic membranes also induced IL-6. Essentially similar results were obtained with representative M. luteus cells and a cell wall specimen in MDP-primed C3H/HeJ mice. These results indicate that M. luteus has virulence activities that are associated with the induction of septic shock and systemic inflammatory diseases.

本文言語English
ページ(範囲)49-55
ページ数7
ジャーナルFEMS Immunology and Medical Microbiology
17
1
DOI
出版ステータスPublished - 1997 1

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 微生物学
  • 免疫学
  • 微生物学(医療)
  • 感染症

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