Microchip-based liquid-liquid extraction for gas-chromatography analysis of amphetamine-type stimulants in urine

Hajime Miyaguchi, Manabu Tokeshi, Yoshikuni Kikutani, Akihide Hibara, Hiroyuki Inoue, Takehiko Kitamori

研究成果: Article査読

50 被引用数 (Scopus)

抄録

A microchip-based liquid-liquid extraction for the gas chromatography analysis of urine for amphetamine-type stimulants has been developed. Partially modified microchannels with the capillarity restricted modification (CARM) method were employed for stabilizing the interface consisting of 1-chlorobutane and alkalized urine. Reliability of the microchip-based extraction was evaluated with respect to linearity, trueness and precision. As a practical demonstration, methoxyphenamine hydrochloride (50 mg) was administered to three healthy volunteers, and the concentration of methoxyphenamine in their urine was determined by both methods for comparison. This study showed the potential of pressure-driven microfluidics to contribute to the rapid automation analysis in forensic toxicology.

本文言語English
ページ(範囲)105-110
ページ数6
ジャーナルJournal of Chromatography A
1129
1
DOI
出版ステータスPublished - 2006 9月 29
外部発表はい

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 有機化学

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