Microchannel device using self-spreading lipid bilayer as molecule carrier

Kazuaki Furukawa, Hiroshi Nakashima, Yoshiaki Kashimura, Keiichi Torimitsu

研究成果: Article査読

37 被引用数 (Scopus)

抄録

We propose a microchannel device that employs a surface-supported self-spreading lipid bilayer membrane as a molecule carrying medium. The device has a micropattern structure fabricated on a SiO2 surface by photolithography, into which a self-spreading lipid bilayer membrane is introduced as the carrier medium. This system corresponds to a microchannel with a single lipid bilayer membrane height of ∼5 nm, compared with conventional micro-fluidic channels that have a section height and width of at least several μm. The device is beneficial for detecting intermolecular interactions when molecules carried by the self-spreading lipid bilayer collide with each other in the microchannel. The validity of the device was confirmed by observing the fluorescence resonance energy transfer (FRET) between two dye molecules, coumarin and fluorescein.

本文言語English
ページ(範囲)1001-1006
ページ数6
ジャーナルLab on a Chip
6
8
DOI
出版ステータスPublished - 2006
外部発表はい

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生化学
  • 化学 (全般)
  • 生体医工学

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