TY - JOUR
T1 - Methylmercury binds to a low molecular weight substance in rabbit and human erythrocytes
AU - Naganuma, Akira
AU - Imura, Nobumasa
N1 - Funding Information:
Hirabayashi for his technical assistance. We also thank Dr. N. Suguro for his help in collecting human blood. This work was supported in part by a grant from the Environment Agency of Japan.
PY - 1979/3/15
Y1 - 1979/3/15
N2 - Behavior of methylmercury in animal blood was investigated by gel filtration of stroma-free hemolysates from rat, rabbit, and human erythrocytes, treated with methylmercury. In the rabbit and human erythrocytes, methylmercury was bound to a low molecular weight substance rather than hemoglobin, while almost all of methylmercury in the rat erythrocyte was bound to the hemoglobin fraction. The methylmercury-bound substance of low molecular weight in rabbit erythrocytes showed a similar behavior pattern to that of glutathione (GSH) bound with methylmercury on gel filtration with Sephadex G-15 and thin-layer chromatography.
AB - Behavior of methylmercury in animal blood was investigated by gel filtration of stroma-free hemolysates from rat, rabbit, and human erythrocytes, treated with methylmercury. In the rabbit and human erythrocytes, methylmercury was bound to a low molecular weight substance rather than hemoglobin, while almost all of methylmercury in the rat erythrocyte was bound to the hemoglobin fraction. The methylmercury-bound substance of low molecular weight in rabbit erythrocytes showed a similar behavior pattern to that of glutathione (GSH) bound with methylmercury on gel filtration with Sephadex G-15 and thin-layer chromatography.
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U2 - 10.1016/0041-008X(79)90532-5
DO - 10.1016/0041-008X(79)90532-5
M3 - Article
C2 - 442099
AN - SCOPUS:0018769789
SN - 0041-008X
VL - 47
SP - 613
EP - 616
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 3
ER -