Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus

Yohei Kera, Yasutake Katoh, Mineto Ohta, Mitsuyo Matsumoto, Teruko Takano-Yamamoto, Kazuhiko Igarashi

研究成果: Article

38 被引用数 (Scopus)

抄録

Background: MATII biosynthesizes AdoMet, which supplies methyl group for methylation of molecules, including histone. Results: MATII interacts with histone methyltransferase SETDB1 and inhibits COX-2 gene expression. Conclusion: AdoMet synthesis and histone methylation are coupled on chromatin by a physical interaction of MATII and SETDB1 at the MafK target genes. Significance: MATII may be important for both gene-specific and epigenome-wide regulation of histone methylation.

本文言語English
ページ(範囲)13592-13601
ページ数10
ジャーナルJournal of Biological Chemistry
288
19
DOI
出版ステータスPublished - 2013 5 10

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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