Metallothionein-mediated resistance to multiple drugs can be induced by several anticancer drugs in mice

Yoichi Okazaki, Nobuhiko Miura, Masahiko Satoh, Nobumasa Imura, Akira Naganuma

研究成果: Article査読

30 被引用数 (Scopus)

抄録

We examined the role of metallothionein in the chemosensitivity of transplanted tumors in mice. The antitumor activities of cisplatin, adriamycin, bleomycin, peplomycin, cyclophosphamide, and melphalan were significantly suppressed when the concentration of metallothionein in the tumor was increased to only twice the control level. On the other hand, the antitumor activities of mitomycin C, 5-fluorouracil, and vinblastine were hardly affected by increases in the concentration of metallothionein in the tumors in mice. Moreover, all the antitumor drugs examined increased the concentration of metallothionein in transplanted tumors to a level that was high enough to suppress the antitumor activity of these drugs. These observations suggest that treatment of patients with certain antitumor drugs might result in the resistance of their tumors to multiple drugs.

本文言語English
ページ(範囲)815-818
ページ数4
ジャーナルBiochemical and biophysical research communications
245
3
DOI
出版ステータスPublished - 1998 4月 28
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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