Metallothionein

A. Naganuma

研究成果: Review article

1 引用 (Scopus)

抜粋

Metallothionein is a low-molecular weight protein involved in resistance to toxicity of heavy metals. Recent experimental evidences indicate that metallothionein appears to be a factor in determining the responsiveness of tumor cells to anticancer drugs, such as cisplatin and adriamycin. The resistance of tumor cells having high concentration of metallothionein to cisplatin has been observed in cultured cells and transplanted tumors. On the other hand, increase in metallothionein concentration in normal tissues of tumor-bearing animals prevents side effects of anticancer drugs. Metallothionein may be an important endogenous factor in cancer chemotherapy.

元の言語English
ページ(範囲)1091-1095
ページ数5
ジャーナルNippon rinsho. Japanese journal of clinical medicine
55
発行部数5
出版物ステータスPublished - 1997 5

ASJC Scopus subject areas

  • Medicine(all)

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