Metal components analysis of metallothionein-III in the brain sections of metallothionein-I and metallothionein-II null mice exposed to mercury vapor with HPLC/ICP-MS

Satomi Kameo, Kunihiko Nakai, Naoyuki Kurokawa, Tomokazu Kanehisa, Akira Naganuma, Hiroshi Satoh

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The influences of the lack of metallothionein (MT)-I and MT-II on mercury accumulation in the brain and the changes of zinc and copper concentrations and metal components of MTs were examined after mercury vapor exposure by using MT-I, II null mice and 129/Sv mice as experimental animals. Metal components of metal-binding proteins of soluble fractions in the brain sections were analyzed by high-performance liquid chromatography (HPLC) connected with inductively coupled plasma mass spectrometry (ICP-MS). The Hg levels of MT-I, II null mice in each brain section were significantly higher than those of wild-type mice after mercury vapor exposure. It was suggested that MT-III is associated with the storage of mercury in conditions lacking MT-I and MT-II.

本文言語English
ページ(範囲)1514-1519
ページ数6
ジャーナルAnalytical and Bioanalytical Chemistry
381
8
DOI
出版ステータスPublished - 2005 4

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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