Metabolic fate of L-[methyl-11C]methionine in human plasma

Kiichi Ishiwata, Jun Hatazawa, Kazuo Kubota, Motonobu Kameyama, Masatoshi Itoh, Taiju Matsuzawa, Toshihiro Takahashi, Ren Iwata, Tatsuo Ido

研究成果: Article査読

33 被引用数 (Scopus)

抄録

The metabolites of L-[methyl-11C]methionine in the plasma of 8 patients with tumor were measured for 60 min after injection. In the plasma, after a rapid clearance, the total radioactivity remained constant, and protein-bound radioactivity increased rapidly. Non protein metabolites detected by HPLC as at least two components besides methionine, increased with time. Significant individual variations for the metabolism were observed. AT 60 min after injection, 36.5% (range: 16%-72%) and 45.3% (range: 13%-74%) of the 11C was measured as methionine and labeled proteins, respectively.

本文言語English
ページ(範囲)665-669
ページ数5
ジャーナルEuropean Journal of Nuclear Medicine
15
10
DOI
出版ステータスPublished - 1989 10

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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