Melanocytes contribute to the vasculature of the choroid

Hirotoshi Shibuya, Ryutaro Watanabe, Akiteru Maeno, Kaoru Ichimura, Masaru Tamura, Shigeharu Wakana, Toshihiko Shiroishi, Koji Ohba, Kazuhisa Takeda, Hiroshi Tomita, Shigeki Shibahara, Hiroaki Yamamoto

研究成果: Article

2 被引用数 (Scopus)

抄録

Melanocytes develop from the vertebrate embryo-specific neural crest, migrate, and localize in various organs, including not only the skin but also several extracutaneous locations such as the heart, inner ear and choroid. Little is known about the functions of extracutaneous melanocytes except for cochlear melanocytes, which are essential for hearing ability. In this study, we focused on the structure of the choroid, in which melanocytes are abundant around the well-developed blood vascular system. By comparing structural differences in the choroid of wild-type and melanocyte-deficient Mitfmi-bw/Mitfmi-bw mutant mice, our observations suggest that choroidal melanocytes contribute to the morphogenesis and/or maintenance of the normal vasculature structure of that tissue.

元の言語English
ページ(範囲)51-58
ページ数8
ジャーナルGenes and Genetic Systems
93
発行部数2
DOI
出版物ステータスPublished - 2018

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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